![]() However, certain regulatory variants around LCT confer a phenotype that maintains intestinal lactase activity at childhood levels into adulthood, thus allowing adult carriers to digest fresh milk safely ( Swallow, 2003). Ancestrally, adult humans are lactose intolerant – losing their childhood ability to digest lactose – and endure severe intestinal distress should they consume fresh milk. A now classic example of a selective sweep in humans is the region around the lactase gene (LCT Bersaglieri et al., 2004 Tishkoff et al., 2006). ![]() While selective sweeps are thought to have been rare in human evolutionary history ( Hernandez et al., 2011), there are a few strong candidates in the human genome. Hernandez, in Encyclopedia of Evolutionary Biology, 2016 Examples of Selective Sweeps
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